Article
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
Diabetes - 1 Oct 2013
Yaghootkar Hanieh, Lamina Claudia, Scott Robert A, Dastani Zari, Hivert Marie-France, Warren Liling L, Stancáková Alena, Buxbaum Sarah G, Lyytikäinen Leo-Pekka, Henneman Peter, Wu Ying, Cheung Chloe Y Y, Pankow James S, Jackson Anne U, Gustafsson Stefan, Zhao Jing Hua, Ballantyne Christie M, Xie Weijia, Bergman Richard N, Boehnke Michael, el Bouazzaoui Fatiha, Collins Francis S, Dunn Sandra H, Dupuis Josee, Forouhi Nita G, Gillson Christopher, Hattersley Andrew T, Hong Jaeyoung, Kähönen Mika, Kuusisto Johanna, Kedenko Lyudmyla, Kronenberg Florian, Doria Alessandro, Assimes Themistocles L, Ferrannini Ele, Hansen Torben, Hao Ke, Häring Hans, Knowles Joshua W, Lindgren Cecilia M, Nolan John J, Paananen Jussi, Pedersen Oluf, Quertermous Thomas, Smith Ulf, Lehtimäki Terho, Liu Ching-Ti, Loos Ruth J F, McCarthy Mark I, Morris Andrew D, Vasan Ramachandran S, Spector Tim D, Teslovich Tanya M, Tuomilehto Jaakko, van Dijk Ko Willems, Viikari Jorma S, Zhu Na, Langenberg Claudia, Ingelsson Erik, Semple Robert K, Sinaiko Alan R, Palmer Colin N A, Walker Mark, Lam Karen S L, Paulweber Bernhard, Mohlke Karen L, van Duijn Cornelia, Raitakari Olli T, Bidulescu Aurelian, Wareham Nick J, Laakso Markku, Waterworth Dawn M, Lawlor Debbie A, Meigs James B, Richards J Brent, Frayling Timothy M
Abstract excerpt
Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but its causal role remains controversial. We used a Mendelian randomization approach to test the hypothesis that adiponectin causally influences insulin resistance and type 2 diabetes. We used genetic variants at the ADIPOQ gene as instruments to calculate a regression slope between adiponectin levels and metabolic traits...
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