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Article

Nonalcoholic Fatty Liver Disease and Estimated Insulin Resistance in Obese Youth: A Mendelian Randomization Analysis

25 Aug 2020

Abstract excerpt

CONTEXT: Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance (IR) and predicts type 2 diabetes. Currently, it is uncertain whether NAFLD may directly cause IR or vice versa. OBJECTIVE: To test the hypothesis that NAFLD is causally related to IR. DESIGN AND METHODS: We performed a Mendelian randomization (MR) in 904 obese children/adolescents using an NAFLD-related genetic risk score...

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Share to Diabetes, Cardiovascular Risks, and Lipoproteins
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PMID: 32841326
DOI: 10.1210/clinem/dgaa583

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