Article
Human thymocyte development in mouse organ cultures.
International immunology - 1 Jan 1990
Fisher A G, Larsson L, Goff L K, Restall D E, Happerfield L, Merkenschlager M
Abstract excerpt
A novel system to study human thymocyte development is described in which embryonic mouse thymic rudiments are seeded with human precursor cells in vitro. In these cultures human thymocytes proliferate extensively (greater than 20-fold increase in cell number) and mature, as evidenced by the accu...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- Cell Division
- Chimera
- Hematopoietic Stem Cells
- Humans
- Mice
- Mice, Inbred BALB C
- Organ Culture Techniques