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Article

Human thymocyte development in mouse organ cultures.

International immunology - 1 Jan 1990

Fisher A G, Larsson L, Goff L K, Restall D E, Happerfield L, Merkenschlager M

Abstract excerpt

A novel system to study human thymocyte development is described in which embryonic mouse thymic rudiments are seeded with human precursor cells in vitro. In these cultures human thymocytes proliferate extensively (greater than 20-fold increase in cell number) and mature, as evidenced by the accumulation of double and single positive (CD4+ and/or CD8+) cells. Data presented here suggest that the survival and...

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Identifiers

PMID: 2128187
DOI: 10.1093/intimm/2.6.571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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