Article
Human neonatal thymic organ culture: an ex vivo model of thymocyte ontogeny and HIV-1 infection.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1994
Rosenzweig M, Bunting E M, Damico R L, Clark D P, Gaulton G N
Abstract excerpt
An intact thymic microenvironment is required for the normal maturation and selection of thymocytes. This process is directed by the interaction of thymocyte progenitors with molecules on the surface of thymic stromal cells and with cytokines. The precise nature of these events is poorly understood in humans. We have developed a technique of human neonatal thymic organ culture (hNTOC) that enabled thymocyte...
Topics
- Flow Cytometry
- HIV-1
- Humans
- Infant, Newborn
- Interleukins
- Lymphocyte Count
- Organ Culture Techniques
- Phenotype
- T-Lymphocyte Subsets
- T-Lymphocytes
- Thymus Gland