Article

Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition of Laminin in Mammals

2025-04-29

Abstract excerpt

Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components can be produced both locally and by distant tissues. In contrast, mammalian ECM has traditionally been considered to originate predominantly from adjacent or tissue-resident cells. The kidney glomerular basement membrane (GBM), composed of laminin-α5β2γ1 and collage...

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Literature Corpus work: 661976ce-79cc-5a4c-9c1e-db9b3eaf3fa5
DOI: 10.1101/2025.04.28.650774

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