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Article

Contribution of the α8 integrin chain to the expression of extracellular matrix components.

Cell communication & adhesion - 1 Apr 2014

Volkert Gudrun, Jahn Angelika, Dinkel Christina, Fahlbusch Fabian, Zürn Christina, Hilgers Karl F, Rascher Wolfgang, Hartner Andrea, Marek Ines

Abstract excerpt

In the kidney, the α8 integrin chain (itga8) is expressed in mesenchymal cells and is upregulated in fibrotic disease. We hypothesized that itga8 mediates a profibrotic phenotype of renal cells by promoting extracellular matrix and cytokine expression. Genetic itga8 deficiency caused complex changes in matrix expression patterns in mesangial and smooth-muscle cells, with the only concordant effect in both cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24460181
DOI: 10.3109/15419061.2013.876012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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