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Article

Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation.

The Journal of biological chemistry - 14 Jul 2006

Lakhe-Reddy Sujata, Khan Shenaz, Konieczkowski Martha, Jarad George, Wu Karen L, Reichardt Louis F, Takai Yoshimi, Bruggeman Leslie A, Wang Bingcheng, Sedor John R, Schelling Jeffrey R

Abstract excerpt

Alpha(v)beta8 integrin expression is restricted primarily to kidney, brain, and placenta. Targeted alpha(v) or beta8 deletion is embryonic lethal due to defective placenta and brain angiogenesis, precluding investigation of kidney alpha(v)beta8 function. We find that kidney beta8 is localized to glomerular mesangial cells, and expression is decreased in mouse models of glomerulosclerosis, suggesting that beta8...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulosclerosis, Focal Segmental

Share to Guanine Nucleotide Dissociation Inhibitors

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Share to Mice, Transgenic

Share to rac1 GTP-Binding Protein

Source

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Identifiers

PMID: 16690620
DOI: 10.1074/jbc.M601110200
PMCID: PMC2711893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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