Article
Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry.
Breast cancer research : BCR - 31 Jan 2011
Smith Letitia D, Tesoriero Andrea A, Wong Ee M, Ramus Susan J, O'Malley Frances P, Mulligan Anna Marie, Terry Mary Beth, Senie Ruby T, Santella Regina M, John Esther M, Andrulis Irene L, Ozcelik Hilmi, Daly Mary B, Godwin Andrew K, Buys Saundra S, Fox Stephen, Goldgar David E, Giles Graham G, Hopper John L, Southey Melissa C
Abstract excerpt
INTRODUCTION: Selecting women affected with breast cancer who are most likely to carry a germline mutation in BRCA1 and applying the most appropriate test methodology remains challenging for cancer genetics services. We sought to test the value of selecting women for BRCA1 mutation testing on the basis of family history and/or breast tumour morphology criteria as well as the value of testing for large genomic...
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