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Article

Clinical significance of large rearrangements in BRCA1 and BRCA2.

Cancer - 1 Nov 2012

Judkins Thaddeus, Rosenthal Eric, Arnell Christopher, Burbidge Lynn Anne, Geary Wade, Barrus Toby, Schoenberger Jeremy, Trost Jeffrey, Wenstrup Richard J, Roa Benjamin B

Abstract excerpt

BACKGROUND: Current estimates of the contribution of large rearrangement (LR) mutations in the BRCA1 (breast cancer 1, early onset) and BRCA2 (breast cancer 2, early onset) genes responsible for hereditary breast and ovarian cancer are based on limited studies of relatively homogeneous patient populations. The prevalence of BRCA1/2 LRs was investigated in 48,456 patients with diverse clinical histories and...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 22544547
DOI: 10.1002/cncr.27556
PMCID: PMC3532625

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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