Article

Analysis of BRCA1 large genomic rearrangements to identify individuals at risk of breast cancer

2020-04-30

Abstract excerpt

<title>Abstract</title> <p>Background. Breast cancer (BC) is a malignant neoplasm in which genetic and environmental aspects contribute to its development. In many cases, pathogenic mutations in BRCA1 are caused by large genomic rearrangements such as copy number variations, a mechanism of gene inactivation that increases the risk of BC. Therefore, identifying women at high risk of BC through genetic testing is o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1f52df4-1770-53c3-84a0-7ec98c253282
DOI: 10.21203/rs.3.rs-22497/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of BRCA1 large genomic rearrangements to identify individuals at risk of breast cancerDOI 10.21203/rs.3.rs-22497/v1Read

Using MLPA for large genomic rearrangements detection in breast cancer predisposition genes.Semantic proximity Read

Identification of a novel BRCA1 large genomic rearrangement in a Spanish breast/ovarian cancer family.Semantic proximity Read

Frequency and distribution of BRCA1/BRCA2 large genomic rearrangements in Turkish population with breast cancer.Semantic proximity Read

Comprehensive mutation detection of BRCA1/2 genes reveals large genomic rearrangements contribute to hereditary breast and ovarian cancer in Chinese womenSemantic proximity Read

Germline mutations of breast cancer susceptibility genes through expanded genetic analysis in unselected Colombian patients.Semantic proximity Read

Identification and comprehensive characterization of large genomic rearrangements in the BRCA1 and BRCA2 genes.Semantic proximity Read

High occurrence of BRCA1 intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech RepublicSemantic proximity Read

The contribution of large genomic rearrangements in BRCA1 and BRCA2 to South African familial breast cancer.Semantic proximity Read

Genomic rearrangements at the BRCA1 locus in Spanish families with breast/ovarian cancer.Semantic proximity Read

A novel BRCA1 duplication and new insights on the spectrum and frequency of germline large genomic rearrangements in BRCA1/BRCA2.Semantic proximity Read

A multi-institutional study of the prevalence of BRCA1 and BRCA2 large genomic rearrangements in familial breast cancer patients.Semantic proximity Read

A novel BRCA1 duplication and new insights on the spectrum and frequency of germline large genomic rearrangements in BRCA1/BRCA2Semantic proximity Read