Article
What is a functional locus? Understanding the genetic basis of complex phenotypic traits.
Medical hypotheses - 1 May 2011
Ruiz-Narváez Edward A
Abstract excerpt
A multitude of results from genome-wide association studies have been published in recent years in relation to different human diseases and phenotypic traits. However, the identified polymorphisms explain just a small fraction of the variability of the traits and they are poor predictors of occurrence of disease. Although part of the missing variability may be found in still to be identified rare genetic...
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