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Article

Genetic variation within transcriptional regulatory elements and its implications for human disease.

Biological chemistry - 1 Dec 2014

Rada-Iglesias Alvaro

Abstract excerpt

Common human pathologies have a complicated etiology involving both genetic and environmental risk factors. Moreover, the genetic basis of these disorders is also complex, with multiple and weak genetic variants contributing to disease susceptibility. In addition, most of these risk genetic variants occur outside genes, within the vast non-coding human genomic space. In this review I first illustrate how...

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Share to Epigenesis, Genetic
Share to Genetic Predisposition to Disease
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Regulatory Elements, Transcriptional

Source

Identifiers

PMID: 25205712
DOI: 10.1515/hsz-2014-0109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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