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Article

The impact of age and CYP2C9 and VKORC1 variants on stable warfarin dose in the paediatric population.

British journal of haematology - 1 Jun 2014

Vear Susan I, Ayers Gregory D, Van Driest Sara L, Sidonio Robert F, Stein Charles Michael, Ho Richard H

Abstract excerpt

The influence of genetic variation on warfarin dose requirement is limited for paediatric patients. We performed a retrospective, cross-sectional study to examine the effect of variant CYP2C9 and VKORC1 genotypes on warfarin dose in 100 children. Those with VKORC1 genotype AA required 48% of the dose of homozygous wild-type (GG, P < 0·0001). Patients with any variant CYP2C9 allele required 71% of the dose for...

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Source

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Identifiers

PMID: 24601977
DOI: 10.1111/bjh.12817
PMCID: PMC4043918

Genes

VKORC1

Provenance

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