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Article

Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2011

Wang Ke-Yong, Tanimoto Akihide, Guo Xin, Yamada Sohsuke, Shimajiri Shohei, Murata Yoshitaka, Ding Yan, Tsutsui Masato, Kato Seiya, Watanabe Teruo, Ohtsu Hiroshi, Hirano Ken-Ichi, Kohno Kimitoshi, Sasaguri Yasuyuki

Abstract excerpt

OBJECTIVE: Histamine and histamine receptors are found in atherosclerotic lesions, and their signaling and subsequent proatherogenic or proinflammatory gene expression are involved in atherogenesis. In the present study, we generated apolipoprotein E (apoE) and histamine synthesizing histidine decarboxylase double knockout (DKO) mice on a C57BL/6J (wild-type mice) background to clarify the roles of histamine in...

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Identifiers

PMID: 21273563
DOI: 10.1161/ATVBAHA.110.215228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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