Evaluation of tyrosine-kinase receptor c-KIT (c-KIT) mutations, mRNA and protein expression in canine leukemia: might c-KIT represent a therapeutic target?

doi:10.1016/j.vetimm.2013.01.003

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Evaluation of tyrosine-kinase receptor c-KIT (c-KIT) mutations, mRNA and protein expression in canine leukemia: might c-KIT represent a therapeutic target?

Veterinary immunology and immunopathology - 15 Apr 2013

Giantin M, Aresu L, Aricò A, Gelain M E, Riondato F, Martini V, Comazzi S, Dacasto M

Abstract excerpt

The tyrosine-kinase receptor c-KIT (c-KIT) plays an important role in proliferation, survival and differentiation of progenitor cells in normal hematopoietic cells. In human hematological malignancies, c-KIT is mostly expressed by progenitor cell neoplasia and seldom by those involving mature cells. Tyrosine kinase inhibitors (TKIs) are actually licensed for the first- and second-line treatment of human...

Topics

Animals
Base Sequence
Case-Control Studies
DNA Mutational Analysis
Dog Diseases
Dogs
Exons
Female
Humans
Leukemia
Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Protein Kinase Inhibitors

Proto-Oncogene Proteins c-kit

RNA, Messenger

RNA, Neoplasm

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Open in PubMed

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PMID: 23375718
DOI: 10.1016/j.vetimm.2013.01.003

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