Article
Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling.
Cardiovascular research - 22 Feb 2021
Alesutan Ioana, Luong Trang T D, Schelski Nadeshda, Masyout Jaber, Hille Susanne, Schneider Markus P, Graham Delyth, Zickler Daniel, Verheyen Nicolas, Estepa Misael, Pasch Andreas, Maerz Winfried, Tomaschitz Andreas, Pilz Stefan, Frey Norbert, Lang Florian, Delles Christian, Müller Oliver J, Pieske Burkert, Eckardt Kai-Uwe, Scherberich Juergen, Voelkl Jakob
Abstract excerpt
AIMS: Uromodulin is produced exclusively in the kidney and secreted into both urine and blood. Serum levels of uromodulin are correlated with kidney function and reduced in chronic kidney disease (CKD) patients, but physiological functions of serum uromodulin are still elusive. This study investigated the role of uromodulin in medial vascular calcification, a key factor associated with cardiovascular events and...
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