Article
A cytotoxic T-lymphocyte clone derived from mice with progressively growing tumors.
Archives of surgery (Chicago, Ill. : 1960) - 1 Apr 1991
Hoover S K, Inge T H, Frank J L, McKinnon G, Monaco J, Susskind B, Bear H D
Abstract excerpt
Tumor-specific T-cell clones were derived from spleen cells of mice bearing a syngeneic PHS-5 tumor (a P815 mastocytoma mutant). Cells were expanded in vitro and characterized and assayed for activity against the relevant tumor in vivo. Clone cells were CD4-, CD8+ T lymphocytes, as determined by fluorescence activated cell sorting analysis and were specifically cytotoxic against P815 tumor cells in vitro, as...
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