Phenotype analyses and cellular mechanisms of the pre-effector T-lymphocyte response to a progressive syngeneic murine sarcoma.

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Article

Phenotype analyses and cellular mechanisms of the pre-effector T-lymphocyte response to a progressive syngeneic murine sarcoma.

Cancer research - 15 Jul 1990

Sakai K, Chang A E, Shu S Y

Abstract excerpt

Lymph nodes draining the progressively growing, weakly immunogenic, MCA 105 sarcoma contained tumor-sensitized but not fully functional pre-effector T-cells. These cells could further differentiate to acquire full antitumor effector function for adoptive therapy in an established in vitro sensitization (IVS) procedure. In this study, we utilized selective depletion with antibodies of lymphocyte subsets bearing...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
CD4 Antigens
CD8 Antigens
Cytotoxicity, Immunologic
Female
Immunotherapy
Lymph Nodes
Lymphatic Metastasis
Lymphocyte Depletion
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Neoplasm Transplantation

Phenotype

Sarcoma, Experimental

T-Lymphocytes

Transplantation, Isogeneic

Source

Open in PubMed

Identifiers

PMID: 2114215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2114215-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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