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Article

Association between toll-like receptor 4 gene polymorphism and biopsy-proven giant cell arteritis.

The Journal of rheumatology - 1 Jul 2009

Palomino-Morales Rogelio, Torres Orlando, Vazquez-Rodriguez Tomas R, Morado Inmaculada C, Castañeda Santos, Callejas-Rubio Jose L, Miranda-Filloy Jose A, Fernandez-Gutierrez Benjamin, Martin Javier, Gonzalez-Gay Miguel A

Abstract excerpt

OBJECTIVE: Dendritic cells localized at the adventitia-media border of the normal medium-sized arteries play a pivotal role in the initiation of giant cell arteritis (GCA). These cells express a singular surface receptor profile, including a series of Toll-like receptors (TLR). Ligands of TLR-4 promote activation and differentiation of adventitial dendritic cells and are directly implicated in the pathogenesis of...

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Source

Identifiers

PMID: 19531762
DOI: 10.3899/jrheum.081286

Genes

GCA
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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