Article
A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples.
BMC medical genomics - 26 Jan 2011
Lisovich Alex, Chandran Uma R, Lyons-Weiler Maureen A, LaFramboise William A, Brown Ashley R, Jakacki Regina I, Pollack Ian F, Sobol Robert W
Abstract excerpt
BACKGROUND: Genomic instability in cancer leads to abnormal genome copy number alterations (CNA) as a mechanism underlying tumorigenesis. Using microarrays and other technologies, tumor CNA are detected by comparing tumor sample CN to normal reference sample CN. While advances in microarray technology have improved detection of copy number alterations, the increase in the number of measured signals, noise from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.