Article
Polymorphisms in EGFR and VEGF contribute to non-small-cell lung cancer survival in a Chinese population.
Carcinogenesis - 1 Jun 2010
Dong Jing, Dai Juncheng, Shu Yongqian, Pan Shiyang, Xu Lin, Chen Wenping, Wang Yi, Jin Guangfu, Ma Hongxia, Zhang Mingfeng, Hu Zhibin, Shen Hongbing
Abstract excerpt
Over the last decades, combined chemotherapies that inhibit different signalling pathways together have been demonstrated to be more effective to treat the non-small-cell lung cancer (NSCLC). The epidermal growth factor receptor (EGFR) and the vascular endothelium growth factor (VEGF) are two key targets. Polymorphisms in EGFR and VEGF genes have been identified to be associated with therapy-response and cancer...
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