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Article

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

The Journal of biological chemistry - 18 Mar 2011

Barbagallo Alessia P M, Wang Zilai, Zheng Hui, D'Adamio Luciano

Abstract excerpt

The Aβ-precursor protein (APP) intracellular domain is highly conserved and contains many potentially important residues, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo, we created an APP knock-in allele mutating Tyr(682) to Gly (Y682G). Crossing this allele to APP-like protein 2 (APLP2) knock-out background showed that mutation of Tyr(682) results in postnatal...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21266574
DOI: 10.1074/jbc.C111.219873
PMCID: PMC3059018

Genes

APP
APLP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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