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Article

A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 2013

Matrone Carmela

Abstract excerpt

Emerging evidence supports the role for the intracellular domains of amyloid precursor protein (APP) in the physiology and function of APP. In this short report, I discuss the hypothesis that mutation of Tyr682 on the Y682 ENPTY687 C-terminal motif of APP may be directly or indirectly associated with alterations in APP functioning and activity, leading to neuronal defects and deficits. Mutation of Tyr682 induces...

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Identifiers

PMID: 23943322
DOI: 10.1002/bies.201300041
PMCID: PMC4033529

Genes

APP
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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