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Article

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth.

The Journal of pathology - 1 Jun 2008

Needham B E, Wlodek M E, Ciccotosto G D, Fam B C, Masters C L, Proietto J, Andrikopoulos S, Cappai R

Abstract excerpt

The amyloid precursor protein (APP), the source of the neurotoxic amyloid beta (A beta) peptide involved in Alzheimer's disease (AD), belongs to a conserved family of related proteins. In mammals, the APP family contains amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2). Whilst a number of activities have been attributed to the APP family, an overall function has not been...

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Source

Identifiers

PMID: 18393365
DOI: 10.1002/path.2343

Genes

APP
APLP2
APLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth.PMID 18393365Read ↗

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Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.Semantic proximity Read ↗

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.Semantic proximity Read ↗

Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic PlasticitySemantic proximity Read ↗

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