Article
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Feb 2005
Wang Pei, Yang Guang, Mosier Dennis R, Chang Paul, Zaidi Tahire, Gong Yan-Dao, Zhao Nan-Ming, Dominguez Bertha, Lee Kuo-Fen, Gan Wen-Biao, Zheng Hui
Abstract excerpt
Biochemical and genetic studies place the amyloid precursor protein (APP) at the center stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead to dominant inheritance of familial AD, the normal function of APP remains elusive. Here, we report that the APP family of proteins plays an essential role in the development of neuromuscular synapses. Mice deficient in APP and its homolog...
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