Article
Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.
Journal of cell science - 15 Feb 2011
Zigler J Samuel, Zhang Cheng, Grebe Rhonda, Sehrawat Gitanjali, Hackler Laszlo, Adhya Souvonik, Hose Stacey, McLeod D Scott, Bhutto Imran, Barbour Walid, Parthasarathy Geetha, Zack Donald J, Sergeev Yuri, Lutty Gerard A, Handa James T, Sinha Debasish
Abstract excerpt
Phagocytosis of the shed outer segment discs of photoreceptors is a major function of the retinal pigmented epithelium (RPE). We demonstrate for the first time that βA3/A1-crystallin, a major structural protein of the ocular lens, is expressed in RPE cells. Further, by utilizing the Nuc1 rat, in which the βA3/A1-crystallin gene is mutated, we show that this protein is required by RPE cells for proper degradation...
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