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Article

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.

Human molecular genetics - 1 Mar 2000

D'Cruz P M, Yasumura D, Weir J, Matthes M T, Abderrahim H, LaVail M M, Vollrath D

Abstract excerpt

Vertebrate photoreceptor cells are the basic sensory apparatus of the retina, capable of converting the energy of absorbed photons into neuronal signals. The proximal portions of mammalian photoreceptor outer segments are synthesized daily by cell bodies, and outer segment tips are shed with a circadian rhythm, resulting in a complete turnover of outer segments about every 9 days. The shed outer segments are...

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Source

Identifiers

PMID: 10699188
DOI: 10.1093/hmg/9.4.645

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.PMID 10699188Read ↗

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MERTK mutation update in inherited retinal diseases.Semantic proximity Read ↗

Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosaSemantic proximity Read ↗

Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis.Semantic proximity Read ↗

Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.Semantic proximity Read ↗

A Comprehensive Review of Mutations in the MERTK Proto-Oncogene.Semantic proximity Read ↗

Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat.Semantic proximity Read ↗

Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.Semantic proximity Read ↗

Clinical characterisation of a family with retinal dystrophy caused by mutation in the Mertk gene.Semantic proximity Read ↗

Characterisation of severe rod-cone dystrophy in a consanguineous family with a splice site mutation in the MERTK gene.Semantic proximity Read ↗

Detection and validation of novel mutations in MERTK in a simplex case of retinal degeneration using WGS and hiPSC-RPEs model.Semantic proximity Read ↗

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