Article
Red blood cells free α-haemoglobin pool: a biomarker to monitor the β-thalassemia intermedia variability. The ALPHAPOOL study.
British journal of haematology - 1 Oct 2017
Vasseur Corinne, Domingues-Hamdi Elisa, Ledudal Katia, Le Corvoisier Philippe, Barau Caroline, Ghaleh Bijan, Rialland Amandine, Pissard Serge, Galactéros Frédéric, Baudin-Creuza Véronique
Abstract excerpt
The severity of β-thalassaemia (β-thal) intermedia is mainly correlated to the degree of imbalanced α/non α-globin chain synthesis. The phenotypic diversity of β-thal depends on this imbalance and reflects all possible combinations of α- and β-globin genotypes, levels of fetal haemoglobin (HbF) and co-inheritance of other modulating factors. This study aimed to demonstrate the validity of a new surrogate of α/non...
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