Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.

Scientific reports - 7 Jan 2022

Sheikh Abdalla, Jackson Jennie, Shim Hanjoo Brian, Yau Clement, Seo Jung Hee, Abraham Ninan

Abstract excerpt

Interleukin-7 (IL-7) is a cytokine known for its importance in T cell development and survival. How IL-7 shapes CD8 T cell responses during an acute viral infection is less understood. We had previously shown that IL-7 signaling deficient mice have reduced accumulation of influenza-specific CD8 T cells following influenza infection. We sought to determine whether IL-7 affects early CD8 T cell expansion in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Interleukin-7

Share to Interleukin-7 Receptor alpha Subunit

Share to Lymph Nodes

Share to Orthomyxoviridae Infections

Share to Programmed Cell Death 1 Receptor

Source

Open in PubMed Open full text

Identifiers

PMID: 34997007
DOI: 10.1038/s41598-021-03936-y
PMCID: PMC8741933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.PMID 34997007Read ↗

IL-7 is essential for accumulation of antigen-specific CD8 T cells and to generate clonotype-specific effector responses during airway influenza/A infectionSemantic proximity Read ↗

Interleukin-7: Fuel for the autoimmune attack.Semantic proximity Read ↗

IRF7 deficiency increases disease severity independently of TLR7 recognition in Influenza A infection in miceSemantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer.Semantic proximity Read ↗

IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways.Semantic proximity Read ↗

Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection.Semantic proximity Read ↗

Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo.Semantic proximity Read ↗

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapySemantic proximity Read ↗

Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7Semantic proximity Read ↗

Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7Semantic proximity Read ↗

Interleukin-7 administration alters intestinal intraepithelial lymphocyte phenotype and function in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.