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Article

Gain-of-function mutations in Trim71 linked to congenital hydrocephalus.

PLoS biology - 1 Feb 2023

Chen Yingying, Yang Xianfa, Jing Naihe

Abstract excerpt

The genetic basis of congenital hydrocephalus is only partially understood. A new study in PLOS Biology reports a potential gain-of-function pathological mechanism of congenital hydrocephalus in mouse embryonic stem cells that involves Wnt-β-catenin signaling pathway regulation.

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Source

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Identifiers

PMID: 36757939
DOI: 10.1371/journal.pbio.3001993
PMCID: PMC9910648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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