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Article

Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Roher Alex E, Kuo Yu-Min, Esh Chera, Knebel Carmen, Weiss Nicole, Kalback Walter, Luehrs Dean C, Childress Jennifer L, Beach Thomas G, Weller Roy O, Kokjohn Tyler A

Abstract excerpt

Alzheimer's disease (AD) is characterized by neurofibrillary tangles and by the accumulation of beta-amyloid (Abeta) peptides in senile plaques and in the walls of cortical and leptomeningeal arteries as cerebral amyloid angiopathy (CAA). There also is a significant increase of interstitial fluid (ISF) in cerebral white matter (WM), the pathological basis of which is largely unknown. We hypothesized that the...

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PMID: 12865947
PMCID: PMC1430731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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