Article
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging - 1 Aug 2007
Thal Dietmar Rudolf, Larionov Sergey, Abramowski Dorothee, Wiederhold Karl-Heinz, Van Dooren Tom, Yamaguchi Haruyasu, Haass Christian, Van Leuven Fred, Staufenbiel Matthias, Capetillo-Zarate Estibaliz
Abstract excerpt
The deposition of the amyloid beta-protein (Abeta) is a hallmark of Alzheimer's disease (AD). One reason for Abeta-accumulation and deposition in the brain may be an altered drainage along perivascular channels. Extracellular fluid is drained from the brain towards the cervical lymph nodes via perivascular channels. The perivascular space around cerebral arteries is the morphological correlative of these drainage...
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