Article
Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele.
PloS one - 1 Jan 2012
Hawkes Cheryl A, Sullivan Patrick M, Hands Sarah, Weller Roy O, Nicoll James A R, Carare Roxana O
Abstract excerpt
Failure of elimination of amyloid-β (Aβ) from the brain and vasculature appears to be a key factor in the etiology of sporadic Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In addition to age, possession of an apolipoprotein E (APOE) ε4 allele is a strong risk factor for the development of sporadic AD. The present study tested the hypothesis that possession of the APOE ε4 allele is associated...
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