Article
Variants in ZNF365 isoform D are associated with Crohn's disease.
Gut - 1 Aug 2011
Haritunians Talin, Jones Michelle R, McGovern Dermot P B, Shih David Q, Barrett Robert J, Derkowski Carrie, Dubinsky Marla C, Dutridge Debra, Fleshner Phillip R, Ippoliti Andrew, King Lily, Leshinsky-Silver Esther, Levine Arie, Melmed Gil Y, Mengesha Emebet, Vasilauskas Eric A, Ziaee Shabnam, Rotter Jerome I, Targan Stephan R, Taylor Kent D
Abstract excerpt
OBJECTIVE: Genome-wide association studies have identified multiple Crohn's disease (CD) susceptibility loci, including association with non-coding intergenic single-nucleotide polymorphisms (SNPs) at 10q21. DESIGN: To fine-map the 10q21 locus, the authors genotyped 86 SNPs in 1632 CD cases and 961 controls and performed single-marker and conditional analyses using logistic regression. RESULTS: Association with...
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