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Article

Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells.

Experimental cell research - 15 Apr 2011

Tsedensodnom Orkhontuya, Koga Hironori, Rosenberg Stephen A, Nambotin Sarah B, Carroll John J, Wands Jack R, Kim Miran

Abstract excerpt

The Wnt/β-catenin signaling pathway is frequently activated in hepatocellular carcinoma (HCC). Downstream signaling events involving the Wnt/β-catenin cascade occur through T-cell factor (TCF) proteins. The human TCF-4 gene is composed of 17 exons with multiple alternative splicing sites. However, the role of different TCF-4 isoforms in the pathogenesis of HCC is unknown. The purpose of this study was to identify...

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Identifiers

PMID: 21256126
DOI: 10.1016/j.yexcr.2011.01.015
PMCID: PMC3066145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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