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Article

Identification of a Novel TCF4 Isoform in the Human Corneal Endothelium.

Cornea - 1 Jul 2018

Eghrari Allen O, Vasanth Shivakumar, Gapsis Briana C, Bison Henry, Jurkunas Ula, Riazuddin S Amer, Gottsch John D

Abstract excerpt

PURPOSE: Alternative splice isoforms of TCF4, a gene implicated in Fuchs corneal dystrophy, have been identified in multiple human tissues outside of the eye. The aim of this study was to identify the transcriptional profile of TCF4 in the corneal endothelium. METHODS: We extracted RNA from the donor corneal endothelium and performed rapid amplification of cDNA ends. We tested the expression pattern of 1 newly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fuchs' Endothelial Dystrophy

Share to Gene Expression Profiling

Share to Protein Isoforms

Share to Transcription Factor 4

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 29677003
DOI: 10.1097/ICO.0000000000001521
PMCID: PMC6482941

Genes

TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Identification of a Novel TCF4 Isoform in the Human Corneal Endothelium.PMID 29677003Read ↗

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CTG18.1 repeat expansion may reduce TCF4 gene expression in corneal endothelial cells of German patients with Fuchs' dystrophy.Semantic proximity Read ↗

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Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated diseaseSemantic proximity Read ↗

Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophySemantic proximity Read ↗

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A common trinucleotide repeat expansion within the transcription factor 4 (TCF4, E2-2) gene predicts Fuchs corneal dystrophy.Semantic proximity Read ↗

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