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Small molecule antagonists of Tcf4/β‐catenin complex inhibit the growth of HCC cells <i>in vitro</i> and <i>in vivo</i>

6 Aug 2009

Abstract excerpt

Hepatocellular carcinoma (HCC) is the 5th most common cancer worldwide. It is intrinsically resistant toward standard chemotherapy, making it imperative to develop novel selective chemotherapeutic agents. The Wnt/beta-catenin pathway plays critical roles in development and oncogenesis, and is dysregulated in HCC. Our study aims to evaluate the activity of 3 small molecule antagonists of the Tcf4/beta-catenin...

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PMID: 19662654
DOI: 10.1002/ijc.24810

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