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Article

Upregulation of T‐cell factor‐4 isoform‐responsive target genes in hepatocellular carcinoma

30 Apr 2013

Abstract excerpt

BACKGROUND: The Wnt/β-catenin signalling pathway regulates genes involved in cell proliferation, survival, migration and invasion through regulation by T-cell factor (TCF)-4 transcription factor proteins. However, the role of TCF-4 isoforms generated by alternative splicing events in hepatocellular carcinoma (HCC) is unknown. AIM: Here, we investigated TCF-4 isoforms (TCF-4J and K)-responsive target genes that...

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PMID: 23651211
DOI: 10.1111/liv.12188

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