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Article

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells.

Molecular cancer - 22 Oct 2009

Yuzugullu Haluk, Benhaj Khemais, Ozturk Nuri, Senturk Serif, Celik Emine, Toylu Asli, Tasdemir Nilgun, Yilmaz Mustafa, Erdal Esra, Akcali Kamil Can, Atabey Nese, Ozturk Mehmet

Abstract excerpt

BACKGROUND: beta-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are associated with chromosomal stability, low histological grade, low tumor invasion and better patient survival. We hypothesized that canonical Wnt signaling is selectively activated in well-differentiated, but repressed in poorly...

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Identifiers

PMID: 19849855
DOI: 10.1186/1476-4598-8-90
PMCID: PMC2770486

Genes

LRP5
LRP6
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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