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Article

Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice.

Leukemia research - 1 May 2011

Sukhai Mahadeo A, Thomas Mariam, Hamadanizadeh Soheila A, Xuan Yali, Wells Richard A, Kamel-Reid Suzanne

Abstract excerpt

Acute promyelocytic leukemia (APL) is a model system of aberrant transcription in cancer. We sought to elucidate the mechanism of action of the variant fusion NuMA-RARα in APL, using the hCG-NuMA-RARα transgenic model. We report that subcellular localization of NuMA-RARα in transgenic mice is dep...

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Identifiers

PMID: 21255834
DOI: 10.1016/j.leukres.2010.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21255834-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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