Article
Exploration of empirical Bayes hierarchical modeling for the analysis of genome-wide association study data.
Biostatistics (Oxford, England) - 1 Jul 2011
Heron Elizabeth A, O'Dushlaine Colm, Segurado Ricardo, Gallagher Louise, Gill Michael
Abstract excerpt
In the analysis of genome-wide association (GWA) data, the aim is to detect statistical associations between single nucleotide polymorphisms (SNPs) and the disease or trait of interest. These SNPs, or the particular regions of the genome they implicate, are then considered for further study. We demonstrate through a comprehensive simulation study that the inclusion of additional, biologically relevant information...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.