The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma.

Abstract excerpt

For major genes known to influence the risk of cancer, an important task is to determine the risks conferred by individual variants, so that one can appropriately counsel carriers of these mutations. This is a challenging task, since new mutations are continually being identified, and there is typically relatively little empirical evidence available about each individual mutation. Hierarchical modeling offers a...

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