Article
Incorporating prior biologic information for high-dimensional rare variant association studies.
Human heredity - 1 Jan 2012
Quintana Melanie A, Schumacher Fredrick R, Casey Graham, Bernstein Jonine L, Li Li, Conti David V
Abstract excerpt
BACKGROUND: Given the increasing scale of rare variant association studies, we introduce a method for high-dimensional studies that integrates multiple sources of data as well as allows for multiple region-specific risk indices. METHODS: Our method builds upon the previous Bayesian risk index by integrating external biological variant-specific covariates to help guide the selection of associated variants and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.