Article
Empirical bayes method for incorporating data from multiple genome scans.
Human heredity - 1 Jan 2005
Beasley T Mark, Wiener Howard, Zhang Kui, Bartolucci Alfred A, Amos Christopher I, Allison David
Abstract excerpt
Individual genome scans tend to have low power and can produce markedly biased estimates of QTL effects. Further, the confidence interval for their location is often prohibitively large for subsequent fine mapping and positional cloning. Given that a large number of genome scans have been conducted, not to mention the large number of variables and subsets tested, it is difficult to confidently rule out type 1...
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