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Article

Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.

Molecular biology and evolution - 4 Sept 2024

Märkle Hanna, John Sona, Metzger Lukas, Ansari M Azim, Pedergnana Vincent, Tellier Aurélien

Abstract excerpt

Host-pathogen coevolution is defined as the reciprocal evolutionary changes in both species due to genotype × genotype (G×G) interactions at the genetic level determining the outcome and severity of infection. While co-analyses of hosts and pathogen genomes (co-genome-wide association studies) allow us to pinpoint the interacting genes, these do not reveal which host genotype(s) is/are resistant to which pathogen...

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PMID: 39172738
DOI: 10.1093/molbev/msae176
PMCID: PMC11414474

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