Article

A waiting time problem arising from the study of multi-stage carcinogenesis

2009-04-01

Abstract excerpt

We consider the population genetics problem: how long does it take before some member of the population has m specified mutations? The case m=2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.

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Identifiers and source

Literature Corpus work: c40458b3-32cc-547c-9e01-a4c005cdd7ee
DOI: 10.1214/08-aap559

Open publication

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