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Influenza A Virus NS1 Induces G0/G1Cell Cycle Arrest by Inhibiting the Expression and Activity of RhoA Protein

3 Jan 2013

Abstract excerpt

Influenza A virus is an important pathogenic virus known to induce host cell cycle arrest in G(0)/G(1) phase and create beneficial conditions for viral replication. However, how the virus achieves arrest remains unclear. We investigated the mechanisms underlying this process and found that the nonstructural protein 1 (NS1) is required. Based on this finding, we generated a viable influenza A virus (H1N1) lacking...

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PMID: 23283961
DOI: 10.1128/jvi.03176-12

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