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Article

Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.

Journal of virology - 1 Oct 2010

Zielecki Florian, Semmler Ilia, Kalthoff Donata, Voss Daniel, Mauel Susanne, Gruber Achim D, Beer Martin, Wolff Thorsten

Abstract excerpt

We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple host proteins, whereas no such motif is found in the NS1 homologues of seasonal human virus...

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Source

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Identifiers

PMID: 20686040
DOI: 10.1128/JVI.00610-10
PMCID: PMC2950580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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