Article
Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.
BMC medical genomics - 27 Oct 2011
Ha Kevin C H, Lalonde Emilie, Li Lili, Cavallone Luca, Natrajan Rachael, Lambros Maryou B, Mitsopoulos Costas, Hakas Jarle, Kozarewa Iwanka, Fenwick Kerry, Lord Chris J, Ashworth Alan, Vincent-Salomon Anne, Basik Mark, Reis-Filho Jorge S, Majewski Jacek, Foulkes William D
Abstract excerpt
BACKGROUND: Gene fusions arising from chromosomal translocations have been implicated in cancer. However, the role of gene fusions in BRCA1-related breast cancers is not well understood. Mutations in BRCA1 are associated with an increased risk for breast cancer (up to 80% lifetime risk) and ovarian cancer (up to 50%). We sought to identify putative gene fusions in the transcriptomes of these cancers using...
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