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Article

The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer.

1 Dec 1990

Abstract excerpt

A vitamin D-responsive element (VDRE) locus within the 5' region of the human osteocalcin gene promoter contains a steroid response-like half-site immediately proximal to a consensus site for the AP-1 nuclear oncogene family. In the studies described here, internal mutagenesis of the osteocalcin promoter coupled to functional assays reveal that the interaction of the vitamin D receptor is limited to the proximal...

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Identifiers

PMID: 2174889
DOI: 10.1016/s0021-9258(18)45821-8

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Related research

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Research trail→

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The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer.PMID 2174889Read ↗

DNA sequences downstream from the vitamin D response element of the rat osteocalcin gene are required for ligand-dependent transactivation.Semantic proximity Read ↗

Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elementsSemantic proximity Read ↗

Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.Semantic proximity Read ↗

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Enhancers Located within Two Introns of the Vitamin D Receptor Gene Mediate Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D<sub>3</sub>Semantic proximity Read ↗

Structural Organization of the Human Vitamin D Receptor Chromosomal Gene and Its PromoterSemantic proximity Read ↗

Structural Organization of the Human Vitamin D Receptor Chromosomal Gene and Its PromoterSemantic proximity Read ↗

Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.Semantic proximity Read ↗

Two Distinct Osteoblast-Specific <i>cis</i>-Acting Elements Control Expression of a Mouse Osteocalcin GeneSemantic proximity Read ↗

Vitamin D receptor interaction with specific DNA. Association as a 1,25-dihydroxyvitamin D3-modulated heterodimer.Semantic proximity Read ↗

Cloning and characterization of the mouse vitamin D receptor promoterSemantic proximity Read ↗

Identification of a Hormone-Responsive Promoter Immediately Upstream of Exon 1c in the Human Vitamin D Receptor Gene*Semantic proximity Read ↗

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